Biomarkers of Chronic Renal Tubulointerstitial Injury
نویسندگان
چکیده
منابع مشابه
Exposure to Nephrotoxins TOXIC CAUSES OF CHRONIC TUBULOINTERSTITIAL RENAL DISEASES
Tubular interstitial structures of the kidney are particularly vulnerable in face of toxic compounds. High concentration of the toxics in de medulla as well as medullary hypoxia and renal hypoperfusion could explain this particularity. Clinical nephrotoxicity involves toxins of diverse origin. The culprits are often registered and non registered drugs either prescribed or purchased over the cou...
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Patients with diabetic nephropathy have a higher risk of mortality, mostly from cardiovascular complications. Standard biomarkers including serum creatinine, estimated glomerular filtration rate, and albuminuria are imprecise, do not directly measure renal tissue injury, and are relatively insensitive to small changes in renal function. Thus, availability of novel biomarkers that are sensitive,...
متن کاملFeaturing of Renal Tubulointerstitial Disease
Dr. Wu’s research interest mainly focuses on Renal Cellular Physiology and Biology, Fluid and Electrolytes disorders, Clinical Nephrology and Renal Replacement Therapy. He has been quite enthusiastic in academic pursuit and published more than 100 articles in various Journals and read more than 50 abstract in various conferences. As the result of his outstanding performance, he has been awarded...
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To demonstrate the renoprotective function of human liver-type fatty acid-binding protein (hL-FABP) expressed in proximal tubules in aldosterone (Aldo)-induced renal injury, hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice received systemic Aldo infusions (Tg-Aldo and WT-Aldo, respectively) were given 1% NaCl water for 28 days. In this model, elevation of systolic blood pressure, mon...
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All components of the endothelin (ET) system are present in renal tubular cells. In this review, we summarize current knowledge about ET and the most common tubular diseases: acute kidney injury (AKI) and polycystic kidney disease. AKI originally was called acute tubular necrosis, pointing to the most prominent morphologic findings. Similarly, cysts in polycystic kidney disease, and especially ...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2019
ISSN: 0022-1554,1551-5044
DOI: 10.1369/0022155419861092